1099 consultant · ~200–900 hrs per funded award · $45–$105/hr · Remote (U.S.)

Rare-Disease Genomics Principal Investigator

Lead the science on our rare-disease genomics work as the named PI, and stand behind every variant call and every claim we make.

About Precision Federal

Precision Federal is a small business building AI, data and software systems for government agencies. The company’s founder loves God, and the company is built on Christian faith: every number we publish is real, every claim we make is verifiable, and the work is done with excellence as service to God. Faith is welcome here and openly shared.

How this role works

You join the bench. You apply with your weekly hours and start time. We set your hourly rate from your résumé, and we may name you on proposals that match this role. If we don't win, you owe nothing.
A contract is awarded. The award funds the team named in the proposal. Your engagement begins at the hourly rate we agreed on.
You work remote, paid from the contract. ~200–900 hrs per funded award — and if no award ever funds, you owe nothing and lose nothing.

What you'll do

Serve as named PD/PI or co-PI, and own the scientific aims, approach and rigor of the work
Review our variant calling, annotation and prioritization pipelines against how rare-disease cases actually get solved
Check variant classifications and diagnostic yield claims against ACMG/AMP criteria and the evidence before they reach the Government
Point us to the right cohorts, knowledgebases and collaborators, such as ClinVar, gnomAD, OMIM or Matchmaker Exchange
Teach our engineers and data scientists what makes a genomic finding credible

Required qualifications

PhD or MD/PhD in genomics, computational genomics, human genetics or a closely related field
A rare-disease genomics research record that includes hands-on clinical variant interpretation
A federally fundable research record as PI or co-I, with an active eRA Commons account and ORCID iD
U.S. citizen or lawful permanent resident (U.S. person)
Willing to be named on a federal proposal with a one-page resume, and to sign a short letter of commitment

Preferred qualifications

Prior federal awards as PD/PI, including SBIR/STTR or multi-PI awards
Clinical genomics laboratory experience, ABMGG certification, or service on a ClinGen expert panel
Exome and genome analysis with GATK, DeepVariant, VEP, Exomiser or comparable tools
Long-read sequencing, RNA-seq for diagnosis, or phenotype-driven prioritization with HPO

Compensation & structure

1099 consulting engagement. $45–$105 per hour; we set your rate from your résumé and experience. Hours are funded by federal contract awards — this seat is scoped at roughly 200–900 hours per funded award, fully remote. Work and pay begin only if the contract is awarded — no award, no hours, no obligation.

Join the bench — Rare-Disease Genomics Principal Investigator

Every application is read. It takes about 5 minutes.

This is a bench, not a job offer. Work starts when we win a contract that needs you.
We may name you on proposals. If that contract is awarded, you do the role at the rate and hours we agree on.
Paid hourly as a 1099 contractor; full-time roles may be W-2. If your background fits, we will email you.

First name *

Last name *

Email *

Phone *

Work authorization *

LinkedIn or portfolio link

What state do you live in? *

Resume (PDF or Word) *

Questions

Answer from your own experience. A few sentences each is plenty; be specific and tell us what you did yourself.

Precision Federal was founded on Christian values. Our faith in God shapes how we work: many of us openly share our personal faith, share our lives together, and pray for one another. We’re building a close-knit community where we truly care about each other. Taking part is always voluntary, and people of every faith and background are welcome. As we get to know you, you’re always welcome to share your own faith with us.

1. Cover letter. In your own words, tell us about yourself: what guides you (for many of us here, that’s our faith in God), your background, and why this role interests you. *

2. Describe the rare-disease genomics project most like this role: the cohort or disease area, the sequencing and data, how variants were interpreted and classified, your role (PI, co-I or other), the funding source, and the result, including publications or diagnoses made. *

Availability

Pay for this role: $45–$105 an hour, set by your experience.

Hours per week you could give on an awarded contract (all part-time, up to 30) *

If you are named and we win, will you be able to start within a few weeks? *

May we name you on proposals for this role, and if we win, will you do the work at the rate we agree on? *

I agree to the Applicant Terms. *

Questions? careers@precisionfederal.com · See all open roles